Ras and Cancer in the 21st Century (Perspectives CSHL)

Van Aelst, Linda,Downward, Julian,McCormick, Frank

ISBN 10: 1621822214 / ISBN 13: 9781621822219

Published by Cold Spring Harbor Laboratory Pr, 2018

About this Item

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Bibliographic Details

• Title: Ras and Cancer in the 21st Century (Perspectives CSHL)
• Publisher: Cold Spring Harbor Laboratory Pr
• Publication Date: 2018
• Language: English
• ISBN 10: 1621822214
• ISBN 13: 9781621822219
• Binding: hardcover
• Condition: Fine

About this title

Synopsis

Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.'

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids).

The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.

About the Author

Linda Van Aelst is with Cold Spring Harbor Laboratory. Julian Downward is with The Francis Crick Institute. Frank McCormick is with the University of California, San Francisco.