Redesigning the Molecules of Life

Steven A. Benner

ISBN 10: 3540191666 / ISBN 13: 9783540191667

Published by Springer Berlin Heidelberg, Springer Apr 1988, 1988

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -The organic chemist is rarely satisfied by a simple 'explanation' of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to 'control' the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of 'understanding,' as it requires the 'prediction' of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Seller Inventory # 9783540191667

Bibliographic Details

• Title: Redesigning the Molecules of Life
• Publisher: Springer Berlin Heidelberg, Springer Apr 1988
• Publication Date: 1988
• Language: English
• ISBN 10: 3540191666
• ISBN 13: 9783540191667
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 244W x 170H x 11D millimeters 244 millimeters width by 170 millimeters height by 11 millimeters depth
• Weight: 329 grams

About this title

Synopsis

The organic chemist is rarely satisfied by a simple "explanation" of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.