Redirection of Th1 and Th2 Responses

Sergio Romagnani

ISBN 10: 3662097117 / ISBN 13: 9783662097113

Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2013, 2013

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -It has been 12 years since the first proposal was made to sub divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI. , this volume). Several of the major, co ordinately regulated, features of allergy, including IgE, eosino philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto kine, IFN-. This suggested that the presence and severity of al lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re cognized for some time (see TRINCHIERI and SCOTI, and COFF MAN et aI. , this volume).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 164 pp. Englisch.

Seller Inventory # 9783662097113

Bibliographic Details

• Title: Redirection of Th1 and Th2 Responses
• Publisher: Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2013
• Publication Date: 2013
• Language: English
• ISBN 10: 3662097117
• ISBN 13: 9783662097113
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 10D millimeters 235 millimeters width by 155 millimeters height by 10 millimeters depth
• Weight: 260 grams

About this title

Synopsis

It has been 12 years since the first proposal was made to sub­ divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis­ eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI. , this volume). Several of the major, co­ ordinately regulated, features of allergy, including IgE, eosino­ philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto­ kine, IFN-. This suggested that the presence and severity of al­ lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif­ ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re­ cognized for some time (see TRINCHIERI and SCOTI, and COFF­ MAN et aI. , this volume).