Reducing GI side effects of NSAIDs by Mutual prodrug approach: Synthesis and evaluation of mutual prodrugs

Walsangikar, Sandeep D., Bhatia, Neela M., Bhatia, Manish S.

ISBN 10: 3846551600 / ISBN 13: 9783846551608

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Reducing GI side effects of NSAIDs by Mutual prodrug approach: Synthesis and evaluation of mutual prodrugs
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3846551600
• ISBN 13: 9783846551608
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimer’s disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach.

About the Author

Mr. Walsangikar S. D. has completed his M. Pharmacy in Pharmaceutical Chemistry. He has published various research papers in international journals as author and contributed as co author in various research papers. He has excellant knowledge of synthetic chemistry. Currently he is working as Assistant Professor at GIPER Satara.