The Reeler Mouse as a Model of Brain Development

Language: English

Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Sep 1998, 1998

3540646744 / 9783540646747

Series: Book 142 of 173 - Advances in Anatomy, Embryology and Cell Biology

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation 'reeler is reelin' has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler. 124 pp. Englisch. …

Seller Inventory # 9783540646747

Title
The Reeler Mouse as a Model of Brain Development
Author
Andre M. Goffinet
Publisher
Springer Berlin Heidelberg, Springer Berlin Heidelberg Sep 1998
Publication year
1998
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3540646744
ISBN 13
9783540646747
Item weight
201 grams
Dimensions
235x155x8 mm
Series
Book 142 of 173: Advances in Anatomy, Embryology and Cell Biology

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

Shipping rates from Germany to U.S.A.

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BuchWeltWeit Ludwig Meier e.K.

Germany