Regulated Cell Death in Neurodegenerative Disorders

Regulated Cell Death in Neurodegenerative Disorders is a comprehensive exploration of the mechanisms and implications of RCD within the realm of neurodegenerative diseases. The book delves into various forms of RCD such as apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death, shedding light on their specific roles in disorders like Alzheimer’s, Parkinson’s, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington’s. Written by leading experts, each chapter offers unique insights into cellular demise, providing valuable information on treatment options and therapeutic targets. The book features 14 chapters that cover molecular, cellular, and pharmacological mechanisms from an applied science perspective.

Topics include the importance of chaperones, kinases, growth factors, inflammaging, mitochondrial dynamics, and oxidative stress. It presents targeted strategies to prevent cell death, reflecting ongoing pursuits in understanding and innovating treatments for neurodegenerative diseases. By offering therapeutic strategies to modulate RCD, this book not only shares knowledge but also provides hope for future advancements in combating these debilitating conditions.

• Provides a comprehensive overview of different types of RCD
• Dissects the crosstalk between different types of RCD
• Explores the relevance of RCD mechanisms to neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington’s disease
• Examines several forms of regulated cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death
• Discusses the effect of Inflammaging and oxidative stress on different types of RCD
• Delves into the effect of chaperones, kinases, and growth factors on different RCD machinery
• Discusses the potential of targeted therapies aimed at interdicting cell death machineries
• Explores disease-modifying agents targeting RCD in neurodegenerative disorders

Heba Mohamed Mansour, Ph.D. is currently the Manager of the Innovative Products' Technical Evaluation Unit at the Central Administration of Biological, Innovative Products, and Clinical Studies (Bio-Inn) at the Egyptian Drug Authority (EDA). She is a topic leader in the ICH working group (EWG S13), specializing in non-clinical safety assessments of oligonucleotide-based therapeutics (ONTs). Heba received a PhD degree in pharmacology and toxicology from the Faculty of Pharmacy, Cairo University in 2024. She also received a diploma in environmental health from Ajloun University, Jordan. Her expertise encompasses a profound understanding of diverse cell death modalities in neurodegeneration and the exploration of potential drug repositioning strategies involving anti-cancer kinase inhibitors for neurodegenerative disorders. Her contributions extend to numerous research articles, prestigious international journal publications, book chapters, books, and comprehensive review articles, solidifying her interest in the field.

Scopus Author ID: 57222590031

Orchid ID: 0000-0001-7102-7305

Aiman Saad El-Khatib, Ph.D. is a Professor of Pharmacology and Toxicology in the Faculty of Pharmacy, Cairo University since May 2002. He is a former vice president of Egyptian Drug Authority (EDA). He held several leadership positions in Cairo University, including Vice President for Graduate Studies and Research Affairs, Dean of Faculty of Pharmacy, Vice Dean for Education and Students Affairs, as well as Vice Dean for Community Service and Environment Development. Additionally, he held the post of Assistant Minister of Health and Population for Pharmaceutical Affairs. His primary research area of interest is the investigation of the pharmacological properties of various drugs, including natural products on the gastrointestinal tract, cardiovascular, and central nervous systems. He published numerous articles in international journals. His awards include Cairo University Scientific Research Fosterage in the field of Theoretical and Applied Biological Sciences in 2004 and Silver and Gold Medal of Merit from the Egyptian Syndicate of Pharmacists in 2004 and 2005.

Scopus Author ID: 7003395602

Orchid ID: 0000-0002-2074-8337