Regulation of B Cell Migration and Antigen Receptor Signaling By Lsc : Regulation of Lsc Activity and Role in B Cell Migration and Antigen Receptor Signaling

Jiancheng Hu

ISBN 10: 3639274725 / ISBN 13: 9783639274721

Published by VDM Verlag Dr. Müller, 2010

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - Cell migration is accomplished by chemoattractant receptors signaling the spatially-restricted activation of rho gtpases. specifically, chemoattractant receptors signal via gai and downstream guanine nucleotide exchange factors (gefs), p-rex and pixa, to activate rac and cdc42 at the leading edge and ultimately leads to cellular protrusion. In contrast, chemoattractant receptor signaling by ga12/13 activate rhoa at the trailing edge and promote cytoskeletal contraction. however, the gef(s) that activate rhoa downstream of chemoattractant receptor and ga12/13 have not been identified. here our study showed that: (1) the activity of lsc is controlled by oligomerization, (2) lsc is a key rhogef that functions as an effector of ga12/13-associated chemoattractant receptors to activate rhoa at the trailing edge and regulate the release of integrin-mediated cell adhesion during cell migration. Besides controlling cell migration, chemoattractant receptor signaling has also been suggested to regulate lymphocyte antigen receptor signaling. our study further revealed that bcr signaling is regulated by lysophosphatidic acid, and the underlying molecular mechanisms of this regulation.

Seller Inventory # 9783639274721

Bibliographic Details

• Title: Regulation of B Cell Migration and Antigen Receptor Signaling By Lsc : Regulation of Lsc Activity and Role in B Cell Migration and Antigen Receptor Signaling
• Publisher: VDM Verlag Dr. Müller
• Publication Date: 2010
• Language: English
• ISBN 10: 3639274725
• ISBN 13: 9783639274721
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 9D millimeters 220 millimeters width by 150 millimeters height by 9 millimeters depth
• Weight: 221 grams

About this title

Synopsis

Cell migration is accomplished by chemoattractant receptors signaling the spatially-restricted activation of rho gtpases. specifically, chemoattractant receptors signal via gai and downstream guanine nucleotide exchange factors (gefs), p-rex and pixa, to activate rac and cdc42 at the leading edge and ultimately leads to cellular protrusion. In contrast, chemoattractant receptor signaling by ga12/13 activate rhoa at the trailing edge and promote cytoskeletal contraction. however, the gef(s) that activate rhoa downstream of chemoattractant receptor and ga12/13 have not been identified. here our study showed that: (1) the activity of lsc is controlled by oligomerization, (2) lsc is a key rhogef that functions as an effector of ga12/13-associated chemoattractant receptors to activate rhoa at the trailing edge and regulate the release of integrin-mediated cell adhesion during cell migration. Besides controlling cell migration, chemoattractant receptor signaling has also been suggested to regulate lymphocyte antigen receptor signaling. our study further revealed that bcr signaling is regulated by lysophosphatidic acid, and the underlying molecular mechanisms of this regulation.

About the Author

Jiancheng Hu is Postdoc Fellow, since 2007, Washington University at St. Louis and Howard Hughes Medical Institute (St. Louis, USA) 2001-2007, PhD, University of Colorado Health Sciences Center (Denver, USA) 1998-2001, MS, Peking University (Beijing, P.R. China) 1992-1996, BS, East China University of Science and Technology (Shanghai, P.R. China)