Regulation and Functional Significance of T-Cell Subsets (Chemical Immunology and Allergy, v. 54)

Coffman, R.L.

ISBN 10: 3805555776 / ISBN 13: 9783805555777

Published by Karger, Switzerland, 1992

About this Item

3805555776. A near fine ex lib. hardcover, appears unread. 132 pages, index, illustrated with charts, tables and diagrams. T-cell heterogeneity in man and experimental animals and implications for infectious and autoimmune diseases. Contents as new.

Seller Inventory # 025131

Bibliographic Details

• Title: Regulation and Functional Significance of T-Cell Subsets (Chemical Immunology and Allergy, v. 54)
• Publisher: Karger, Switzerland
• Publication Date: 1992
• Language: English
• ISBN 10: 3805555776
• ISBN 13: 9783805555777
• Binding: Hardcover
• Condition: Near Fine
• Dust Jacket Condition: No Jacket
• Book Type: Book
• Seller catalogs:
  • Medical Research

About this title

Synopsis

This volume offers a review of T-cell heterogeneity in man and experimental animals and the implications of this heterogeneity for infectious and autoimmune diseases. It has recently become clear that peripheral T cells, both of the CD4+ and CD8+ lineages, can be divided into multiple subsets based on function, cytokine production and surface phenotype. Several articles describe the control of differentiation of these subsets and the phenotypic markers that correlate with specific functions and differentiation stages. Other articles discuss the participation of T-cell subsets in parasitic and mycobacterial diseases, AIDS and autoimmune disease. They describe some of the clearest examples of infectious and autoimmune diseases in which different clinical forms are the result of different T-cell subsets responding to the pathogen. The last article is an extensive review of the mechanisms of delayed-type hypersensitivity, the basic manifestation of cell-mediated immunity. Taken together, these articles provide a cellular and biochemical basis for T-cell regulation of the fundamental dichotomy in immunology - cell-medicated versus humoral immunity.