Reinventing The Breast Cancer

Amrendar Kumar

ISBN 10: 384432304X / ISBN 13: 9783844323047

Published by LAP LAMBERT Academic Publishing Apr 2011, 2011

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in System/Network biology. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention.104 antimutagens were collected from literature survey. Of this only 81 structure were available and taken from the Pubchem database. The PDB ids of the Breast cancer genes were taken. Docking was performed with the help of Quantum docking software and the docking scores were obtained. The list of gene ids obtained is loaded into the VISANT application. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A indicating that Breast cancer specific drugs are specific for the particular disease gene and not random among the networks. The ligands (Antimutagens) show good response to the specific type of cancer. 148 pp. Englisch.

Seller Inventory # 9783844323047

Bibliographic Details

• Title: Reinventing The Breast Cancer
• Publisher: LAP LAMBERT Academic Publishing Apr 2011
• Publication Date: 2011
• Language: English
• ISBN 10: 384432304X
• ISBN 13: 9783844323047
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 9D millimeters 220 millimeters width by 150 millimeters height by 9 millimeters depth
• Weight: 238 grams

About this title

Synopsis

Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in System/Network biology. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention.104 antimutagens were collected from literature survey. Of this only 81 structure were available and taken from the Pubchem database. The PDB ids of the Breast cancer genes were taken. Docking was performed with the help of Quantum docking software and the docking scores were obtained. The list of gene ids obtained is loaded into the VISANT application. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A indicating that Breast cancer specific drugs are specific for the particular disease gene and not random among the networks. The ligands (Antimutagens) show good response to the specific type of cancer.

About the Author

Amrendar Kumar And Abhilasha Singh Amity Institute of Biotechnology, Amity University, Lucknow Biplab Bhattacharjee IOCB, Bangalore