Aims to summarize knowledge about the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. This volume is useful to members of the cancer research community and clinicians interested in developing and implementing novel forms of treatment for cancer. Editor(s): Welch, Danny R. Series: Cancer Metastasis - Biology and Treatment. Num Pages: 270 pages, biography. BIC Classification: MJCL. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 17. Weight in Grams: 581. . 2002. Hardback. . . . . Books ship from the US and Ireland.

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Bibliographic Details

Title: Related Genes
Publisher: Kluwer Academic Publishers
Publication Date: 2002
Language: English
ISBN 10: 1402005229
ISBN 13: 9781402005220
Binding: Hardcover
Condition: New

About this title

Synopsis

Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e. ,

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