Retinoids in Normal Development and Teratogenesis

Retinoic acid is of major importance in the regulation of normal gene expression in both embryonic and adult cells, through binding to, and activation of, specific retinoic acid receptors in the nucleus. Other nuclear receptors may bind to different retinoids. In the embryo, tissue and stage-specific distribution patterns of the different receptors, and of the cytoplasmic retinoid binding proteins, provide an underlying basis for the richly varied and changing pattern of retinoid-related developmental gene expression. This book provides an up-to-date review of recent progress in understanding the roles of retinoids in both normal and abnormal differentiation, morphogenesis, and pattern formation. It integrates molecular, cellular and embryonic approaches.

'it will be a valuable reference for those who want to penetrate into the field of retinoids, and perhaps also to those that already are in the field' Ulf Eriksson, BioEssays, Vol. 15, No. 6 - June 1993 'The book combines work in embryology and development, and in molecular biology and clinical pathology, thus providing an extremely valuable overview ... a very interesting collection of papers ... the book does collect together much valuable material.' E.J. Wood, Retinoids Today and Tomorrow 30