Rheumatoid Arthritis : Recent Research Advances

Ravinder N. Maini

ISBN 10: 3642761917 / ISBN 13: 9783642761911

Published by Springer, 2011

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Many advances have occurred in the last 5 years especiallyin understanding genetic susceptibility factors, the role ofimmune response in chronic arthritis and the relationshipbetween cellular processes that underlie inflammation andtissue damage. All these are dealt with in depth in theindividual contributions.Genetics studies included illustrate how studies of HLAgenes and genes controlling the autoantibody repertoire maybe involved. Environmental factors are believed to beimportant and studies both in humans and in experimentalmodels on the role of viral and bacterial agents arecovered. The fascinating relationship between microbesdysregulated immune responses and oncogenes are alsoexamined.Since autoimmunity is the key aspect of the immunologicalresponse in rheumatoid arthritis, the role of antigens isre-examined as is the part played by immune T and B cells.New areas of clinical application of basic science is wellpresented in this book, forexample, in examining howmarkers of cartilage destruction may become important inmonitoring disease activity. A chapter reviewing possiblefuture novel therapies is included.

Seller Inventory # 9783642761911

Bibliographic Details

• Title: Rheumatoid Arthritis : Recent Research Advances
• Publisher: Springer
• Publication Date: 2011
• Language: English
• ISBN 10: 3642761917
• ISBN 13: 9783642761911
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 23D millimeters 235 millimeters width by 155 millimeters height by 23 millimeters depth
• Weight: 639 grams

About this title

Synopsis

Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.