Role of the CD63 Expression Test on Basophils in Drug Allergy | CD63 expression test on basophils in drug allergy diagnosis

Violeta Kvedariene (u. a.)

ISBN 10: 384544004X / ISBN 13: 9783845440040

Published by LAP Lambert Academic Publishing, 2012

About this Item

Role of the CD63 Expression Test on Basophils in Drug Allergy | CD63 expression test on basophils in drug allergy diagnosis | Violeta Kvedariene (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783845440040 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106631675

Bibliographic Details

• Title: Role of the CD63 Expression Test on Basophils in Drug Allergy | CD63 expression test on basophils in drug allergy diagnosis
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 384544004X
• ISBN 13: 9783845440040
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 6D millimeters 220 millimeters width by 150 millimeters height by 6 millimeters depth
• Weight: 168 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Diagnosis of drug hypersensitivity is indeed based on history and clinical manifestations and on skin and drug provocation tests. There are limitations to the interpretation of in vivo tests as co-factors at the time of onset, the metabolism of drug, the presentation of haptens to the immune system may be different after epicutaneous or oral challenge. Therefore, biological tests would be a highly desirable solution for establishing the nature of the culprit agent. In the present work, the results of the CD63 expression tests on basophils were analysed using a novel distribution depending on the time delay between the reaction and the drug intake, the tested drug concentration and the chemical drug structure, in both immediate and non-immediate reactions. The importance of cut-off values was assessed in immediate and non-immediate reactions induced by “haptenic” molecules. The discordance between the results of specific IgE to β-lactams and the CD63 expression test on basophils was analysed in β-lactam allergic patients. The subgroup of patients with severe drug-induced reactions was assessed to evaluate the results of CD63 expression tests in clinical practice.

About the Author

Violeta Kvedarienė PhD, MD is consulting allergist at the Vilnius University Hospital, Vilnius, Lithuania. The main topic of the research work is to establish the value of the flow - assisted analysis of in vitro-activated basophils for drug hypersensitivity diagnosis. The research work conducted at the Montpellier University Hospital, France.