SAR: Side Effects and Drug Design (Medicinal Research Series, Vol. 11)

SAR focuses on the quantitative structure-activity relationship (QSAR) of the disposition and activities of various pharmacological groups – the first systematic approach for linking different side effects of drugs to their molecular structure and physiochemical properties.

This unique monograph describes the application of molecular modification to the practical improvement of therapeutic agents; depicts the quantitative measurement of biological activity as it relates to QSAR; provides essential guidance on selecting suitable mathematical models, defining appropriate parameters in correlation studies and anticipating potential side effects during the tedious drug development process.

Eric J. Lien is Professor of Pharmacy and Biomedical Chemistry at the University of Southern California School of Pharmacy, Los Angeles. Dr. Lien is the author of SAR Analysis and Anticancer Chinese Drugs and Related Plants and U.S. New Drug Digest, 1980-86, as well as over 160 scientific papers and chapters in pharmaceutical textbooks. He is on the editorial boards of Journal of Clinical and Hospital Pharmacy and Oriental Healing Arts International Bulletin. A member of many scientific and professional societies, Dr. Lien also serves as a consultant to the National Institutes of Health. He received the B.S. (1960) degree in pharmacy from the School of Pharmacy, College of Medicine, National Taiwan University, Ph.D. (1966) degree in pharmaceutical chemistry from the University of California, San Francisco Medical Center, and did postdoctoral work (1968) at Pomona College, Claremont, California.