SNEDDS for improved oral Bioavailability of BCS classII drug-IVIVC | Self nanoemulsifying drug delivery system of poorly soluble drug Olnzapine for enhanced oral bioavailability and IVIVC

Raman Sureshkumar (u. a.)

ISBN 10: 3659440485 / ISBN 13: 9783659440489

Published by LAP LAMBERT Academic Publishing, 2013

About this Item

SNEDDS for improved oral Bioavailability of BCS classII drug-IVIVC | Self nanoemulsifying drug delivery system of poorly soluble drug Olnzapine for enhanced oral bioavailability and IVIVC | Raman Sureshkumar (u. a.) | Taschenbuch | 68 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659440489 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 105702164

Bibliographic Details

• Title: SNEDDS for improved oral Bioavailability of BCS classII drug-IVIVC | Self nanoemulsifying drug delivery system of poorly soluble drug Olnzapine for enhanced oral bioavailability and IVIVC
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659440485
• ISBN 13: 9783659440489
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 119 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Modern drug discovery technique led to the consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble. A great challenge facing the pharmaceutical scientist is making these molecules into orally administered medications with sufficient bioavailability. One of the most popular approaches to improve the oral bioavailability of these molecules is the utilization of a lipid based drug delivery system. Development and optimization of formulation is an integral part of manufacturing and marketing of any therapeutic agent which is indeed a time consuming and costly process. Optimization process may require alteration in formulation composition, manufacturing process, equipment and batch sizes. If these types of changes are applied to a formulation, studies in human healthy volunteers may be required to prove that the new formulation is bioequivalent with the old one.IVIVC includes in vivo relevance to in vitro dissolution specifications and can serve as surrogate for in vivo bioavailability and to support biowaivers. This book provides the information about the use of biorelevant media as media an alternative for in vivo studies.

About the Author

Raman Sureshkumar works in the department of Pharmaceutics JSS College of Pharmacy,Ootacamund affiliated to JSS University Mysore. Thrust area of interest is in enhancing bioavailability of poorly soluble drugs through nanoemulsion technology. To his credit he has published papers in both International and national journals also 2 patents filed.