STRUCTURE FUNCTION AND MODULATION OF

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

VALENTIN K. GRIBKOFF, PHD, is the Chief Scientific Officer and Senior Vice President of Discovery Research at Knopp Neurosciences. He is also an Adjunct Associate Professor in the Department of Pharmacology at Yale University School of Medicine. Dr. Gribkoff has published 100 articles and holds twelve patents.

LEONARD K. KACZMAREK, PHD, is a Professor in the Departments of Pharmacology and Molecular and Cellular Physiology at Yale University School of Medicine. Dr. Kaczmarek has edited or authored two books and over 200 articles. He has served on the editorial boards of The Journal of Neuroscience, Journal of Molecular Neuroscience, The Journal of Experimental Biology, and New Biologist.