Seeking Molecular Biomarkers for Schizophrenia Using ROC Analysis

Language: English

Published by Springer, Springer Nature Switzerland Jun 2025, 2025

3031595858 / 9783031595851

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Neuware -Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases.…

Seller Inventory # 9783031595851

Title
Seeking Molecular Biomarkers for Schizophrenia Using ROC Analysis
Author
Margareth Borges Coutinho Gallo
Publisher
Springer, Springer Nature Switzerland Jun 2025
Publication year
2025
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3031595858
ISBN 13
9783031595851
Item weight
411 grams
Dimensions
235x155x15 mm

Wegmann1855

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