Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

Language: English

Published by Springer, Springer Jun 2012, 2012

3642196829 / 9783642196829

Series: Book 28 of 173 - Advances in Anatomy, Embryology and Cell Biology

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This item is printed on demand - Print on Demand Titel. Neuware -The skin, the body¿s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-¿ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endingsto alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 132 pp. Englisch.…

Seller Inventory # 9783642196829

Title
Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System
Author
Andrzej T. Slominski
Publisher
Springer, Springer Jun 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3642196829
ISBN 13
9783642196829
Item weight
213 grams
Dimensions
235x155x8 mm
Series
Book 28 of 173: Advances in Anatomy, Embryology and Cell Biology

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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