Separation Methods in Drug Synthesis and Purification (Handbook of Analytical Separations)

Valko

ISBN 10: 0444500073 / ISBN 13: 9780444500076

Published by Elsevier Science, 2000

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Bibliographic Details

• Title: Separation Methods in Drug Synthesis and Purification (Handbook of Analytical Separations)
• Publisher: Elsevier Science
• Publication Date: 2000
• Language: English
• ISBN 10: 0444500073
• ISBN 13: 9780444500076
• Binding: Hardcover
• Condition: Like New
• Book Type: book

About this title

Synopsis

Hardbound. The new technologies in drug research such as combinatorial chemistry, high throughput screening, and robotics have made it possible to synthesise millions of molecules for thousands of screens. This volume presents the theory and applications of a wide range of separation methods used in the early stages of drug synthesis, purification and characterisation. The topics covered are high performance liquid chromatography, capillary electrophoresis, capillary electro-chromatography, enantioseparations, preparative chromatography, and thin-layer chromatography. The separation methods used for the determination of physical-chemical properties together with the quantitative structure–retention relationship studies are also reviewed. The academic contributors provide a detailed description of the basic principles while the industrial contributors give real life examples of their application. The book not only reviews the major achievements i

About the Author

Dr. Klára Valkó is an enthusiastic principal scientist and consultant supporting early drug discovery and lead optimization with over 22 years of experience. She has been an Honorary Professor at UCL School of Pharmacy since 2004, leading the Physchem/ADME module (London, UK) for Drug Discovery MSc. Her many contributions to the field include the development of biomimetic HPLC methods for high throughput measurements of serum albumin, glycoprotein and phospholipid binding, the invention of the Chromatographic Hydrophobicity Index for fast determination of compounds’ lipophilicity using generic gradient reversed phase chromatography, and more.