Sequence Alignment: Methods, Models, Concepts, and Strategies

ISBN 10: 0520271319 / ISBN 13: 9780520271319

Published by University of California Press, 2011

About this Item

Seller Inventory # mon0003504360

Bibliographic Details

Title: Sequence Alignment: Methods, Models, ...

Publisher: University of California Press

Publication Date: 2011

Binding: paperback

Condition: Very Good

About this title

Synopsis:

The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences—making sure that sequences from one source are properly compared to those from other sources—remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field's leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

From the Inside Flap:

"Sequence alignment represents the final frontier in the development of repeatable, comprehensive methods for phylogenetic analysis. This book will inform readers about the current status of alignment methods and will help stimulate additional work in the field."—David M. Hillis, University of Texas

"Sequence Alignment provides an in-depth treatment of the prerequisite to many evolutionary analyses by presenting a diversity of opinions on the best way to align complex molecular sequence data. Topics covered include the basic algorithms used, global versus local procedures, the robustness alignment error detection, and a description of the programs now available. Sequence Alignment is a reassuring companion, guiding the reader through a large and complicated field."—John Huelsenbeck, Department of Integrative Biology, University of California, Berkeley