Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately.
This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function.
The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.
..".the editors recruited the most distinguished scientists in special areas as coauthors. Through the contributions of about 60 individual authors, a book developed, which covers not only the state of the art of signal transduction, but a volume that can serve as a source of knowledge and stimulating inspiration for interested students and investigators."
- The Quarterly Review of Biology
..".a one-stop shop for signaling information....it excels in providing information on just about any aspect of signal transduction imaginable...written by a veritable who's who of the signaling field...it is a magnum opus and should be a reference source..."
- Science Signaling
"The comprehensive nature of this superb textbook, as well as its careful and lucid writing, clear illustrations, and extensive references, makes it a must read for graduate students and research personnel."
- Choice
"I give this book an excellent review, with regard to its clear explanations and use of diagramming to illustrate cell communication."
- Olive Branch United Blog
..".the editors recruited the most distinguished scientists in special areas as coauthors. Through the contributions of about 60 individual authors, a book developed, which covers not only the state of the art of signal transduction, but a volume that can serve as a source of knowledge and stimulating inspiration for interested students and investigators."
- The Quarterly Review of Biology
..".a one-stop shop for signaling information....it excels in providing information on just about any aspect of signal transduction imaginable...written by a veritable who's who of the signaling field...it is a magnum opus and should be a reference source..."
- Science Signaling
"The comprehensive nature of this superb textbook, as well as its careful and lucid writing, clear illustrations, and extensive references, makes it a must read for graduate students and research personnel."
- Choice
"I give this book an excellent review, with regard to its clear explanations and use of diagramming to illustrate cell communication."
- Olive Branch United Blog
