Signaling by Receptor Tyrosine Kinases (Cold Spring Harbor Perspectives in Biology)

Joseph Schlessinger,Mark A. Lemmon

ISBN 10: 1936113333 / ISBN 13: 9781936113330

Published by Cold Spring Harbor Press 2013-11-30, 2013

About this Item

Seller Inventory # 6666-GRD-9781936113330

Bibliographic Details

• Title: Signaling by Receptor Tyrosine Kinases (Cold Spring Harbor Perspectives in Biology)
• Publisher: Cold Spring Harbor Press 2013-11-30
• Publication Date: 2013
• Language: English
• ISBN 10: 1936113333
• ISBN 13: 9781936113330
• Binding: Hardcover
• Condition: New

About this title

Synopsis

Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF), and molecules involved in neuronal guidance. Ligand binding stimulates the tyrosine kinase activity of the receptors, leading to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation, differentiation, and numerous other biological processes.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the mechanisms underlying receptor tyrosine kinase signaling, including ligand processing, receptor dimerization, receptor trafficking, and the roles of adapters. The contributors also survey the specific functions of the different subfamilies of receptors and examine their many roles in development and normal physiology.

In addition, the authors review the important roles of these proteins in insulin resistance and cancer. This volume is thus a vital reference for cell and developmental biologists as well as those working on cancer biology, diabetes, and obesity.

About the Author

Joseph Schlessinger is William H. Prusoff Professor and Chairman of the Department of Pharmacology at Yale University School of Medicine.