In Silico Design of Hemolysin Inhibitors: of Staphylococcus haemolyticus and Wet Laboratory Applications

Abdulmohsin, Bakr Mohammed Ali

ISBN 10: 3659909491 / ISBN 13: 9783659909498

Published by LAP Lambert Academic Publishing, 2019

About this Item

144 pages. 8.66x5.91x0.47 inches. In Stock.

Seller Inventory # 3659909491

Bibliographic Details

• Title: In Silico Design of Hemolysin Inhibitors: of Staphylococcus haemolyticus and Wet Laboratory Applications
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2019
• Language: English
• ISBN 10: 3659909491
• ISBN 13: 9783659909498
• Binding: Paperback
• Condition: Brand New
• Weight: 0.25 kilograms

About this title

Synopsis

Staphylococcus haemolyticus strains are the second of the most frequently encountered Coagulase Negative Staphylococci that have been recognized as an emerging and important human pathogen causing serious infections such as endocarditis, urinary tract infections, septicemia, peritonitis, wound, bone and joint infections. Patients with the illnesses are usually immunocompromised, with indwelling or implanted foreign bodies . In Silico drug design represents a new approach for drug discovery and industry. This approach was used in this study to find multi-target inhibitors against the hemolysin proteins of the Staphylococcus haemolyticus which is considered the main virulence factor of this bacterium. One hundred thirty two samples were collected from wounds, ear swaps, blood cultures and from urine samples of Iraqi patients for bacterial identification from 1/12/2013 to 28/4/2014 period. Forty six of samples were diagnosed as Staphylococcus haemolyticus by biochemical tests. Almost all isolates had the ability to produce hemolysin at different degrees.