Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique

Chaudhary Haresh, Patel B N, Patel D M

ISBN 10: 384650405X / ISBN 13: 9783846504055

Published by LAP Lambert Academic Publishing, 2014

About this Item

Seller Inventory # LU-9783846504055

Bibliographic Details

• Title: Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2014
• Language: English
• ISBN 10: 384650405X
• ISBN 13: 9783846504055
• Binding: Paperback
• Condition: New
• Dimensions: 15.01W x 0.71H x 22D centimeters 15.01 centimeters width by 0.71 centimeters height by 22 centimeters depth
• Weight: 191 grams

About this title

Synopsis

Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.

About the Author

Haresh Chaudhary has completed B.pharm and M.pharm from Shri Sarvajanik Pharmacy College,Mehsana and currently working in Formulation Development Department at Cadila Healthcare Ltd, Ahmedabad. He is energetic person with positive attitude toward his goal.