Skin Aging & Cancer: Ambient UV-R Exposure

This book summarizes the potent effect of ultraviolet radiation (UVR) on the photoaging and cancer formation. Skin is the largest human organ which continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. This protection can be compromised by the aging of the skin which ultimately promotes skin inflammation, impaired wound repair, and increased risk of skin cancer. The book entails mechanistic insights into the UVR-induced immunomodulation and DNA damage in the skin to delineate the pathogenesis, and develop novel ways for prevention of photoaging of the skin cells. It also elucidates the potential of nanotechnology in the treatment of skin cancer. Further, it discusses the bioinformatics approaches to understand the molecular mechanism of photoaging and cancer formation.

Dr. Neeraj Agarwal is working as a Scientist in NCI-designated University of Colorado Comprehensive Cancer Center, Aurora, CO, USA. Previously, he has completed his Ph.D. (2001 to 2007) from Photobiology, Division of Indian Institute of Toxicology Research (IITR), Lucknow.  His work was focused on determining the phototoxic potential of commonly used therapeutic drugsand their mechanism of action. He has published seven research papers and presented his work at various conferences. He has received best poster award in 2002 for the work related to ciprofloxacin phototoxicity. In 2007, he joined Louisiana Health Sciences Center (LSUHSC), New Orleans, USA as a Postdoctoral Researcher and worked for five years towards understating the role of MTBP protein in osteosarcoma metastasis and also on identifying and characterizing the cancer stem cells in osteosarcoma. He has received Scientific Excellence Award and was invited to present his work in Cancer Center Retreat in 2010. Till now, he has published 18 research articles in reputed international journals with high impact factors, including Cancer Research, Oncogene, Cell Death and Differentiation, Clinical Cancer Research, and Photochemistry and Photobiology.

Dr. Lipika Ray is a Scientist in Pharmaceutics and Pharmacokinetics division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow. She has expertise in the field of nanomedicine. Previously, she has done post-doctoral research as a DST-Young Scientist in Photobiology Division, Indian Institute of Toxicology Research (IITR), Lucknow. The project was mainly focused on phototoxicity assessment of bulk and nano-curcumin. Till now, she has fifteen years of research experience and published numerous papers in peer-reviewed journals such as Biomaterials, International Journal of Pharmaceutics, European Journal of Pharmaceutics and Biopharmaceutics, etc.