Solid Dispersion of Dronedarone HCl for Better Dissolution Profile

Subhashis Debnath

ISBN 10: 6202515201 / ISBN 13: 9786202515207

Published by LAP LAMBERT Academic Publishing Mrz 2020, 2020

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Dronedarone is the class III anti arrhythmatic drug of benzofuron derivative having high lipophilicity and less aqueous solubility and less dissolution rate. The bioavailability (absolute) of the drug in absence of food is reported as low which is nearly 4%. The presence of fatty meal increases the bioavailability of dronedarone to nearly about 15%. Thus in this research work a solid dispersion formulation is tried which enhances the oral bioavailability and Dissolution profile of the poorly aqueous soluble Dronedarone HCl. 68 pp. Englisch.

Seller Inventory # 9786202515207

Bibliographic Details

• Title: Solid Dispersion of Dronedarone HCl for Better Dissolution Profile
• Publisher: LAP LAMBERT Academic Publishing Mrz 2020
• Publication Date: 2020
• Language: English
• ISBN 10: 6202515201
• ISBN 13: 9786202515207
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 119 grams

About this title

Synopsis

Dronedarone is the class III anti arrhythmatic drug of benzofuron derivative having high lipophilicity and less aqueous solubility and less dissolution rate. The bioavailability (absolute) of the drug in absence of food is reported as low which is nearly 4%. The presence of fatty meal increases the bioavailability of dronedarone to nearly about 15%. Thus in this research work a solid dispersion formulation is tried which enhances the oral bioavailability and Dissolution profile of the poorly aqueous soluble Dronedarone HCl.