Solid Dispersion as a Solubility Enhancement Technique

Solid dispersion was prepared by solvent evaporation technique and it is optimized by using different of polymer and lipid ratios. The prepared solid dispersions were evaluated for solubility study, assay and in vitro dissolution study. The solid state property was characterized by differential scanning Calorimetry(DSC). The solubility and dissolution rate were found significantly increased in these solid dispersion systems compared with pure drug alone. The highest improvement of solubility and dissolution rate was found with PEG 6000 and 45 mg phosphatidycholine. DSC studies of solid dispersions confirmed the there is no interaction between drug with excipients. This is attributed to improve bioavailability due to enhancement in rate and extent of drug release. The preparation of solid dispersion is a promising strategy to improve the solubility and dissolution of drug of low solubility and thereby bioavailability of the drug. The solvent evaporation method could be considered as a simple method for preparation of solid dispersion within a shorter period of times.

Kalpen N. Patel, M. Pharm in Pharmaceutical Technology.