Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics (Biotechnology: Pharmaceutical Aspects) (Biotechnology: Pharmaceutical Aspects)

Augustijns, Patrick (Editor)/ Brewster, Marcus E. (Editor)

ISBN 10: 0387691499 / ISBN 13: 9780387691497

Published by Amer Assn of Pharmaceutical, 2007

About this Item

1st edition. 459 pages. 10.00x7.00x1.00 inches. In Stock.

Seller Inventory # x-0387691499

Bibliographic Details

• Title: Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics (Biotechnology: Pharmaceutical Aspects) (Biotechnology: Pharmaceutical Aspects)
• Publisher: Amer Assn of Pharmaceutical
• Publication Date: 2007
• Language: English
• ISBN 10: 0387691499
• ISBN 13: 9780387691497
• Binding: Hardcover
• Condition: Brand New
• Weight: 1.01 kilograms

About this title

Synopsis

Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.