Specificity, Function, and Development of NK Cells

Marco Colonna

ISBN 10: 3642468616 / ISBN 13: 9783642468612

Published by Springer Berlin Heidelberg Mrz 2012, 2012

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors. 264 pp. Englisch.

Seller Inventory # 9783642468612

Bibliographic Details

• Title: Specificity, Function, and Development of NK Cells
• Publisher: Springer Berlin Heidelberg Mrz 2012
• Publication Date: 2012
• Language: English
• ISBN 10: 3642468616
• ISBN 13: 9783642468612
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 15D millimeters 235 millimeters width by 155 millimeters height by 15 millimeters depth
• Weight: 406 grams

About this title

Synopsis

Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.