The Spontaneously Diabetic Bb Rat: A Model of Autoimmunity and Immunodeficiency

Language: English

Published by Forgotten Books, 2024

0259029386 / 9780259029380

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Print on Demand. This book explores the complex relationship between autoimmunity and immunodeficiency in the spontaneously diabetic BB rat model, providing valuable insights into the pathogenesis of insulin-dependent diabetes (IDD). The author delves into the historical context of IDD research and positions the BB rat model within its significance in understanding the disease. The book comprehensively examines the immune dysregulation observed in BB rats, including the presence of organ-specific autoantibodies, impaired T cell function, and increased susceptibility to infections. The author discusses the potential mechanisms underlying these abnormalities, such as genetic predisposition and environmental factors. Through detailed analyses, the book highlights the similarities and differences between IDD in BB rats and humans, emphasizing the translational potential of this model for studying the disease. The author explores the role of autoimmunity in the development of IDD, examining the presence of pancreatic islet cell antibodies and other autoimmune markers in BB rats. This book offers a comprehensive understanding of the immune dysregulation and autoimmunity in the BB rat model, providing valuable insights for researchers and clinicians working in the field of diabetes and immunology. The author effectively synthesizes current knowledge and presents a compelling argument for the continued use of the BB rat model to unravel the complexities of IDD. This book is a reproduction of an important historical work, digitally reconstructed using state-of-the-art technology to preserve the original format. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in the book.

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Title
The Spontaneously Diabetic Bb Rat: A Model of Autoimmunity and Immunodeficiency
Author
Melissa Ellen Elder
Publisher
Forgotten Books
Publication year
2024
Condition
New
Book Type
print-on-demand item
Binding
Paperback
Language
English
ISBN 10
0259029386
ISBN 13
9780259029380
Seller catalogs
General Medicine

Forgotten Books

London, United Kingdom

5-star seller

AbeBooks seller since June 2, 2021

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Forgotten Books’ Classic Reprint Series utilizes the latest technology to regenerate facsimiles of historically important writings. Careful attention has been made to accurately preserve the original format of each page whilst digitally enhancing the quality of the aged text.

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FB &c Ltd

Dalton House, 60 Windsor Avenue
London, United Kingdom SW19 2RR