A Statistical Approach to Design of Floating Drug Delivery System

This book provides a statistical approach to design and optimization of monolithic gastric floating drug delivery system of anticancer drug, Alfuzosin. Drug delivery system has its main aim to administered appropriate amount of drugs to the target site of the body in order to achieve and maintain the desired therapeutic drug concentration that elicits the desired pharmacological action. Drug absorption of oral route could be inadequate and highly variable in individuals due to physiological variabilities. This can be overcome by developing a suitable gastroretentive drug delivery system, which can prolong the gastric residence time of dosage form thereby improve the drug bio-availability. Floating drug delivery system is considerably easy and logical approach in the development of gastroretentive dosage forms. The oral delivery of anticancer alfuzosin was facilitated by preparing a gastric floating dosage form which could increase its absorption in the gastric region of the stomach by prolonging the gastric residence time of the drug. In the present work, gastric floating tablets were optimized by conventional process and further optimized by statistical methods.

Dr.Venkata Srikanth Meka is a researcher and faculty in School of Pharmacy, International Medical University(IMU), Malaysia. He is having 8 years of research experience in the development of different drug delivery systems. He has published his research findings in 45 national and international journals.He obtained Ph.D from Andhra University,India