A Statistical Approach to Genetic Epidemiology: Concepts and Applications

"There are not so many books on statistical methods focused on genetic epidemiology. This contribution fills a gap with a good selection of topics presented in a concise format that will be useful for biostatisticians starting in the field and geneticists or epidemiologists that want to master the specialized statistics used in genetics." ISCB NEWS

Covering the latest developments, this advanced textbook introduces the relevant statistical methods applied in this field.

• Provides a concise introduction to genetic fundamentals
• Explains both linkage analysis and association analysis in detail
• Features more than 100 problems and solutions
• Includes a foreword by Robert C. Elston, Director, Division of Genetic and Molecular Epidemiology at the Case Western Reserve University, Cleveland, Ohio

Written by the prize-winning scientist Andreas Ziegler, President of the German Region of the International Biometric Society, and Inke Koenig, who contributes several years of teaching experience, this is an ideal text for all epidemiologists, geneticists, statistics specialists, biomathematicians, and graduate students.

After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-S?h-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on "Model Free Linkage Analysis of Quantitative Traits" in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery. Andreas Ziegler is head of the Institute for Medical Biometry and Statistics at the University Clinic Schleswig-Holstein an acknowledged center of excellence for genetic epidemiological methods. Currently he is President of the German Region of the International Biometric Society.

Inke R. Koenig studied psychology at the universities of Marburg (Germany) as a scholar of the German National Academic Foundation and Dundee (Scotland) with a grant from the German Academic Exchange Service (DAAD). She has done research work at the Institute of Medical Biometry and Epidemiology in Marburg and since 2001 at the Institute of Medical Biometry and Statistics in L? In 2004, she became vice director of the latter and also received the Fritz-Linder-Forum-Award from the German Association for Surgery. Besides holding the certificate for Biometrics in Medicine, she has collected teaching experience since 1998 as a lecturer for biomathematics, behavioural genetics, clinical epidemiology, genetic epidemiology, and evidence-based medicine.