Statistical Approach to Study Microarray Analysis Using Bioconductor : Study of gene expression using R Language

Language: English

Published by LAP Lambert Academic Publishing, 2012

3659133418 / 9783659133411

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Microarray is a novel technology to identify gene expression of thousands of genes simultaneously. This work is attempted to perform microarray data analyses to determine differential gene expression using the open-source R programming environment in conjunction with the open-source Bioconductor software.We describe procedures for analysis of data using box plots and recommended procedures from Affymetrix for quality control are discussed. The Robust Multichip Averaging (RMA) and MAS5 procedure was used for background correction, normalization and summarization of the AffyBatch probe-level data to obtain expression level data and to discover differentially expressed genes. Heatmaps are used to demonstrate over and under expressed genes in conjunction with t-statistics for determining interesting genes while pFDR was performed to remove false negative. We showed, with real data, how implementation of functions in R and Bioconductor successfully identified differentially expressed genes that may play a role in obesity.

Seller Inventory # 9783659133411

Title
Statistical Approach to Study Microarray Analysis Using Bioconductor : Study of gene expression using R Language
Author
Drushti Bhatt
Publisher
LAP Lambert Academic Publishing
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659133418
ISBN 13
9783659133411
Item weight
116 grams
Dimensions
220x176x33 mm

AHA-BUCH GmbH

Einbeck, Germany

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