Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes
Language: English
Published by Mit Pr, 2016
- Hardcover
- New
Seller: Equipment for Living, Aliquippa, PA, U.S.A.Equipment for Living
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- Title
- Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes
- Publisher
- Mit Pr
- Publication year
- 2016
- Condition
- new
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 0262034689
- ISBN 13
- 9780262034685
Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits.
Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influencegenetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G × E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use.
The contributors first present different statistical approaches or strategies to address G × E and G × G interactions with high-throughput sequenced data, including two-stage procedures to identify G × E and G × G interactions, marker-set approaches to assessing interactions at the gene level, and the use of a partial-least square (PLS) approach. The contributors then turn to specific complex phenotypes, research designs, or combined methods that may advance the study of G × E interactions, considering such topics as randomized clinical trials in obesity research, longitudinal research designs and statistical models, and the development of polygenic scores to investigate G × E interactions.
Contributors
Fatima Umber Ahmed, Yin-Hsiu Chen, James Y. Dai, Caroline Y. Doyle, Zihuai He, Li Hsu, Shuo Jiao, Erin Loraine Kinnally, Yi-An Ko, Charles Kooperberg, Seunggeun Lee, Arnab Maity, Jeanne M. McCaffery, Bhramar Mukherjee, Sung Kyun Park, Duncan C. Thomas, Alexandre Todorov, Jung-Ying Tzeng, Tao Wang, Michael Windle, Min Zhang
"Synopsis" may belong to another edition of this title.
About the Author
Michael Windle is Professor of Public Health in the Department of Behavioral Sciences and Health Education at Emory University.
"About the title" may belong to another edition of this title.
Equipment for Living
Aliquippa, PA, U.S.A.
AbeBooks seller since October 26, 2025
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Equipment for Living is a socially conscious bookstore located in Aliquippa, Pennsylvania. More than just a retail business, we define ourselves as "a business with a conscience" - committed to fostering community development, meaningful employment, and urban revitalization in Western Pennsylvania. OUR MISSION: Equipment for Living operates on the belief that responsible entrepreneurship can be a powerful force for positive change. We provide valuable retail services while creating meaningful work opportunities that serve as sites of training and mentoring. Our Youth Employment Initiative specifically targets local residents aged 16-25, offering employment, skill development, and guidance during the critical transition from youth to adulthood. We measure success not just in profits, but in empowering our employees to pursue their career aspirations and life goals - even when that means moving on to other opportunities. OUR STORY: Founded in 2008 and opening our physical storefront in 2012 after extensive community-led renovations, Equipment for Living has grown from an online book venture into a cornerstone of Aliquippa's revitalization efforts. We've deliberately chosen to establish our business in this former steel town, recognizing that true community poverty isn't just about lacking economic resources - it's about lacking opportunities, connections, education, and hope. OUR INVENTORY: Equipment for Living offers a refreshingly different retail experience from typical chain bookstores. While big-box stores stock only high-demand, profitable bestsellers in predictable arrangements, we curate a wide and constantly evolving selection that reflects the unique character of our community. Our diverse inventory includes books across all genres and eras, audiobooks, CDs, DVDs, VHS tapes, vinyl records, and video games. We embrace the philosophy that "if you only read the books that everyone else is reading, you can only think what everyone else is thinking." While we may not always have the latest bestseller in stock, we guarantee a carefully selected range of high-quality products you won't easily find elsewhere - true equipment for living a rich, thoughtful life.…
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