Statistical Design and Analysis of Biological Experiments

Hans-Michael Kaltenbach

ISBN 10: 303069643X / ISBN 13: 9783030696436

Published by Springer International Publishing, 2022

About this Item

Druck auf Anfrage Neuware - Printed after ordering - This richly illustratedbook provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields.The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including 'portable power' formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice.Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.

Seller Inventory # 9783030696436

Bibliographic Details

• Title: Statistical Design and Analysis of Biological Experiments
• Publisher: Springer International Publishing
• Publication Date: 2022
• Language: English
• ISBN 10: 303069643X
• ISBN 13: 9783030696436
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 16D millimeters 235 millimeters width by 155 millimeters height by 16 millimeters depth
• Weight: 435 grams

About this title

Synopsis

This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields.

The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice.

Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software.

Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.

About the Author

Dr. Kaltenbach is a Senior Scientist at the ETH Zurich, Switzerland. He holds a diploma in mathematics and a PhD in bioinformatics, and previously worked in industry as a statistical consultant. His research combines statistics and applied mathematics in the context of biology and medicine. He is the author of A Concise Guide to Statistics (2012) and has extensive experience in teaching and consulting on experimental design and statistical analysis in the biological and biomedical sciences.