Stimuli-Responsive Nanocarriers for Targeted Drug Delivery (Paperback)

Stimuli-Responsive Nanocarriers for Targeted Drug Delivery presents a comprehensive overview of the most significant physical and chemical stimuli-responsive drug delivery systems. This book reviews targeted and controlled drug delivery systems and how nanocarriers can be used to improve the pharmacokinetics of drugs in biological systems, such as increasing utilization rate and reducing toxicity and side effects. After a key introduction to the topic, a range of nanocarrier types is assessed before exploring the clinical translation challenges and considerations involved.

This book is a useful resource for researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science, and medicinal chemistry.

• Offers an in-depth look at the basic and fundamental aspects of stimuli-responsive materials, mechanisms, structure, synthesis and properties
• Provides information about well-defined categorization for stimuli-responsive drug delivery system based on different triggering mechanisms to its reader
• Reviews basic concepts and the latest research involving advances in stimuli-responsive drug delivery systems in controlled-release drugs
• Discusses novel approaches and challenges for scaling-up and commercialization of stimuli-responsive polymers

Prof. Muhammad Raza Shah is a professor and Director of the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. He holds four US patents. Dr. Shah has received numerous awards, including the Khwarizmi International Award from the Ministry of Science, Research and Technology, Iran (2023). He has also been honored with the Civil Award Tamgha-i-Imtiaz (2015), Dr. Raziuddin Prize (2015), Prof. Atta-ur-Rahman Gold Medal by the Pakistan Academy of Sciences, Avicenna Science & Innovation Award (2015) by Brain Trust UK, and the Abdus Salam Award in Chemistry (2006). He was named TWAS Young Affiliate in 2010 by The World Academy of Sciences. Prof. Shah is a Fellow of the International Union of Pure and Applied Chemistry, the Chemical Society of Pakistan, the Islamic World Academy of Sciences, and the Royal College of Physicians (Edinburgh). Dr. Shah has conducted 29 Phase-I (BE and PK) studies, 04 Phase-II Randomized Clinical Trial as PI and lead the Phase-I RCT of Sinopharm COVID-19 vaccine and Phase-III RCT of COVID-19 booster vaccine as country PI.

Dr. Tooba Jabri completed her PhD in organic chemistry (2023) at the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. She has been a recipient of a national-level scholarship from the Higher Education Commission (HEC) of Pakistan, and has conducted research as part of the HORIZON 2020 INFUSION project at Cardiff University, United Kingdom. Her focus areas include design and development of nanomaterials, drug delivery system, and synthesis of organic and polymeric materials.

Dr. Maria Khalid earned her MSc in Chemistry (2008) from Quaid e Azam University, graduating at the top of her class and receiving the Chancellor’s Medal for academic excellence, along with a national-level scholarship from the Higher Education Commission (HEC) of Pakistan. Dr. Khalid completed her PhD in 2025 at the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan, focusing on the design and development of innovative polymer-based materials for biomedical and therapeutic applications.