Structural Biology Using Electrons and X-rays: An Introduction for Biologists

Structural Biology Using Electrons and X-rays is the perfect book to provide advanced undergraduates or graduate students with an accessible introduction to the two major diffraction-based techniques of structural biology. While concentrating on electron cryo-microscopy with image analysis, it also includes X-ray crystallography in a coherent survey of fundamental principles. Starting with Fourier transforms and progressing through optics and imaging principles, symmetry and three-dimensional reconstruction theory, Structural Biology Using Electrons and X-rays ends in an account of the latest methods adapted to crystals, helices, viral heads, and single particles.

• Emphasis on common principles underlying all diffraction-based methods
• Thorough grounding in theory requires understanding of only simple algebra
• Visual representations and explanations of challenging content
• Mathematical detail offered in short-course form to parallel the text

Michael Moody has worked in leading laboratories in the United States and Europe and taught at many international electron-microscopy image-analysis courses.