Title: Structure, Activity, and Function of Protein Methyltransferases
Publisher: Mdpi AG
Publication Date: 2022
Language: English
ISBN 10: 303654139X
ISBN 13: 9783036541396
Binding: Hardback
Condition: New
Dimensions: 16.99 centimeters width by 2.39 centimeters height by 24.41 centimeters depth
Weight: 830 grams

About this title

Synopsis

This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field.

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