Structure-Activity Relationships For Pharmacotoxicological Endpoints: Development Of Structure-Activity Relationships For Pharmacotoxicological Endpoints Relevant To European Union Legislation

Lessigiarska, Iglika; P. Worth, Andrew; T.D. Cronin, Mark; Lessigiarska, Iglika; P. Worth, Andrew; T.D. Cronin, Mark

ISBN 10: 3838356802 / ISBN 13: 9783838356808

Published by Lap Lambert Academic Publishing, 2010

About this Item

232 pages. 8.66x5.91x0.53 inches. In Stock.

Seller Inventory # 3838356802

Bibliographic Details

• Title: Structure-Activity Relationships For Pharmacotoxicological Endpoints: Development Of Structure-Activity Relationships For Pharmacotoxicological Endpoints Relevant To European Union Legislation
• Publisher: Lap Lambert Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838356802
• ISBN 13: 9783838356808
• Binding: Paperback
• Condition: Brand New
• Weight: 0.4 kilograms

About this title

Synopsis

Quantitative structure-activity relationships (QSARs) are computer-based mathematical models that give information on the potential biological effects of compounds on the basis of their chemical structure alone. In this book, a research project on the development of QSARs for a range of toxicological endpoints, including cytotoxicity and acute toxicity, and biokinetic parameters related to the penetration of chemical compounds across the blood-brain barrier, is presented. Increasingly, legislation on the assessment and management of chemical risks, such as the REACH (Registration, Evaluation and Authorisation of Chemicals) Regulation in European Union, foresee an expanded use of QSARs as an alternative approach to (animal) testing of toxicity for the regulatory assessment of chemicals and chemical products. The research presented was performed at the Institute for Health & Consumer Protection (IHCP) of the European Commission''s Joint Research Centre (JRC) and at Liverpool John Moores University (LJMU) as a part of Iglika Lessigiarska''s PhD project.

About the Author

Iglika Lessigiarska works in the Group for Molecular Modelling within the Centre of Biomedical Engineering of Bulgarian Academy of Sciences. Andrew Worth leads the Computational Toxicology and Biostatistics Group within the Institute for Health and Consumer Protection of the JRC. Mark Cronin is Professor of Predictive Toxicology at LJMU.