Structure-based Drug Discovery

. Ed(s): Jhoti, Harren; Leach, Andrew R.

ISBN 10: 9048171237 / ISBN 13: 9789048171231

Published by Springer, 2010

Editor(s): Jhoti, Harren; Leach, Andrew R. Num Pages: 250 pages, biography. BIC Classification: MMG; TDCW. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 14. Weight in Grams: 409. . 2010. 1st ed. Softcover of orig. ed. 2007. Paperback. . . . . Books ship from the US and Ireland. Seller Inventory # V9789048171231

Synopsis:

Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

From the Back Cover:

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

Structure-based drug discovery describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being used worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology.

Bibliographic Details

Title: Structure-based Drug Discovery
Publisher: Springer
Publication Date: 2010
Binding: Soft cover
Condition: New