Structure and function of urease and cytochrome c-553: A scientific journey to unravel the mechanism of urea enzymatic hydrolysis, and the role of cytochrome c-553

Benini, Stefano

ISBN 10: 3838364988 / ISBN 13: 9783838364988

Published by LAP LAMBERT Academic Publishing, 2010

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Bibliographic Details

• Title: Structure and function of urease and cytochrome c-553: A scientific journey to unravel the mechanism of urea enzymatic hydrolysis, and the role of cytochrome c-553
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838364988
• ISBN 13: 9783838364988
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

This book provides, through X-ray crystallography, information about the structure and function relationships of urease and cytochrome c-553 from Bacillus pasteurii. Urease is a nickel enzyme involved in nitrogen turnover and in human and animal pathologies. The comparison between the native and the inhibited structures provides information about the active site and the inhibition mechanisms, and allows the proposal of a reaction mechanism which agrees with the available biochemical data. Cytochrome c-553 is a small electron transfer protein. The characterisation at atomic resolution (0.97 A) provides one of the most accurate heme structures to date. Providing a thoroughly written background and an accurate description of all the steps from bacterial growth to structure solution, this book is aimed at researchers interested in structural biology, in protein science and enzymatic catalysis. Useful for graduate and PhD students who are interested in protein crystallography. An easy to read background of protein crystallography is provided in the appendix for the less experienced reader.