Studies on Cardiovascular Disorders (Oxidative Stress in Applied Basic Research and Clinical Practice). This item is unavailable.Studies on Cardiovascular Disorders (Oxidative Stress in Applied Basic Research and Clinical Practice)

Preface Contributor's List Chapters: 1) The evolving concept of oxidative stress Denise de Castro Fernandes, Diego Bonatto, Francisco R. M. Laurindo 2) Mechanisms of redox signaling in cardiovascular disease Rebecca L. Charles, Joseph R. Burgoyne and Philip Eaton 3) Reactive oxygen and nitrogen species in cardiovascular differentiation of stem cells Heinrich Sauer and Maria Wartenberg§ 4) Reactive Oxygen Species (ROS) and the sensory neurovascular component Rabea Graepel BSc, Jennifer Victoria Bodkin BSc, MRes, & Susan Diana Brain BSc, PhD 5) Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Post-Conditioning Ariel R. Cardoso, Bruno B. Queliconi* and Alicia J. Kowaltowski 6) Coenzyme Q9/Q10 and Healthy Heart Samarjit Das, Somak Das and Dipak K. Das 7) Oxidative and proteolytic stress in homocysteine associated cardiovascular diseases Karni S. Moshal, Munish Kumar, Neetu Tyagi, Paras Kumar Mishra, Saumi Kundu, Suresh C. Tyagi 8) Functional studies of NADPH oxidases in human vasculature Tomasz J Guzik 9) Relationship of the CYBA gene polymorphisms with oxidative stress and cardiovascular risk Guillermo Zalba, PhD and Javier Díez, MD, PhD 10) Redox-related genetic markers of cardiovascular diseases Christian Delles, MD, and Anna F. Dominiczak, MD 11) NADPH oxidases and blood-brain barrier dysfunction in stroke Timo Kahles, MD, Sabine Heumüller and Ralf P. Brandes, MD 12) Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular Diseases David Bernhard PhD 13) Oxidative Stress in Vascular Aging Anna Csiszar, MD, PhD and Zoltan Ungvari, MD, PhD 14) Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus Divya Gupta, Kathy K. Griendling and W. Robert Taylor 15) Reactive Oxygen Species, Oxidative Stress and Hypertension Rhian M Touyz MD, PhD, Andreia Chignalia, MSc, Mona Sedeek PhD 16) Peripartum cardiomyopathy: Role of STAT-3 and reactive oxygen species Denise Hilfiker-Kleiner, PhD, Arash Haghikia, MD, andAndres Hilfiker, PhD 17) Oxidative stress and inflammation after coronary angiography Raymond Farah MD 18) Oxidative Stress in Cardiac Transplantation Galen M. Pieper, Ph.D. and Ashwani K. Khanna, Ph.D 19) Oxidative Stress and Atrial Fibrillation Ali A. Sovari and Samuel C. Dudley, Jr. 20) Oxidative stress and the anti-oxidative capacity in myocardial infarction Yao Sun, MD, Ph.D. 21) Oxidative Stress and Redox Signalling in Cardiac Remodelling Min Zhang MD, PhD, Alex Sirker MRCP and Ajay M Shah MD, FmedSci 22) Oxidative Stress and Cardiovascular Fibrosis Subramanian Pennathur, Louise Hecker, and Victor J. Thannickal 23) Oxidative Risk Factors for Cardiovascular Disease in Women M. Gago-Dominguez, Xuejuan Jiang, J. Esteban Castelao 24) Protective effects of food on cardiovascular diseases Alfonso Giovane, Biol.D., Ph.D., and Claudio Napoli, M.D., Ph.D., MBEth. 25) Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications Gloria V. López, PhD and Homero Rubbo, PhD 26) Thioredoxin in the cardiovascular system - towards a thioredoxin-based anti-oxidative therapy Bradford C. Berk 27) The protective effect of melatonin on the heart Amanda Lochner 28) Exercise Induced cardioprotection: Overview with an emphasis on the role of anti-oxidants Karyn L. Hamilton and John C. Quindry 29) Antioxidative properties of statins in the heart Oliver Adam MD, Ulrich Laufs MD

This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.