Study on COX-2 Expression in Breast & Prostrate Cancer patients: Flowcytometric and IF analysis of COX-2 expression

Varma, Saurabh, Mallik, Anwesha

ISBN 10: 3848426153 / ISBN 13: 9783848426157

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Study on COX-2 Expression in Breast & Prostrate Cancer patients: Flowcytometric and IF analysis of COX-2 expression
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3848426153
• ISBN 13: 9783848426157
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Cancer is abnormal division of cells with the ability to invade other tissues. Cancer may be of more than 100 types depending on the origin of organ or cell types in which they start. Breast cancer begins in the cells of the lobule or ducts or in the stromal tissues .Genetic abnormality is also one of the main cause of breast cancer. Whereas prostrate cancer occurs due to mutation and may spread to other parts of body. Immunohistochemical and Immnofluorescence study of COX-2 expression in 29 cancer patient samples was performed. Cyclooxygenase (COX) is an angiogenic factor i.e., strongly related to inflammatory diseases & the development of cancer& metastasis in several cancers. We observed the higher percentage expression of COX-2 in breast & prostate carcinoma using IHC in comparison to IF. Positive immunoreactivity to COX-2 was noted 62.5% by IHC & 72.2% by IF. This study suggests the possible role of the COX-2 in breast & prostate cancer patients .

About the Author

Dr Saurabh Varma completed his PhD from Central Drug Research Institute,then joined AIIMS,India & now working in Indian Council of Medical Research as senior scientist.He has 20 research papers to his credit and has been Guide/ co-guide to one PhD,7 MSc and 2 DNB students. Anwesha mallik is MSc in Botany & having Diploma in Bioinformatics