Study of Meiosis | Molecular Control and Chromosomal Segregation

Himanshu Gupta

ISBN 10: 3846537195 / ISBN 13: 9783846537190

Published by LAP Lambert Academic Publishing, 2013

About this Item

Study of Meiosis | Molecular Control and Chromosomal Segregation | Himanshu Gupta | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783846537190 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106107673

Bibliographic Details

• Title: Study of Meiosis | Molecular Control and Chromosomal Segregation
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3846537195
• ISBN 13: 9783846537190
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 3D millimeters 220 millimeters width by 150 millimeters height by 3 millimeters depth
• Weight: 107 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Reductional nature of meiosis is responsible to maintain the ploidy in eukaryotes. In sexual reproduction, Meiotic division produces gametes of half ploidy and fertilization restores original chromosome number. In the meiosis sister chromatids are monoorientated which leads to separation of homologous chromosomes. This is followed by separation of sister chromatid in meiosis II because of biorientation of sister chromatids. Comparison of meiosis with mitosis reveals that monoorientation of sister chromatids is the main reason for halving the ploidy. According to the present hypothesis, Monopolin complex, A four subunit complex, directs monopolar attachment of sister chromatids. Present study is done to reveal the nature and function of this complex. Cell cycle arrest mutants were created and verified to maximize the number of cells at particular stage by deleting or shuffling the promoter of a particular gene. Then, Csm1 subunit of monopolin complex was affinity tagged and verified in arrested cells. As future prospects of this work affinity purification of Csm1 can be done. Comparison of protein profiles obtained will help to reveal the functional properties of monopolin complex.

About the Author

Himanshu Gupta, M.Sc. Biotechnology graduate from Indian Institute of Technology Bombay. Worked on meiotic cell cycle and area of specialization are Cell biology & Biochemistry. Currently, Lecturer at Amity University Rajasthan, Jaipur, India.