Sunset yellow induced neuronal damage; Protected by Vernonia cinerea : Exploration of the potential of Vernonia cinerea extract to attenuate the sunset yellow induced neuronal damage in mice

Language: English

Published by LAP LAMBERT Academic Publishing, 2021

6203839701 / 9786203839708

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Objective: The study was designed to screen the protective effect of Vernonia cinerea extract against sunset yellow induced anxiogenic behaviour in mice through counteracting oxidative damage.Methods: The anxiogenic effect was induced by the administration of sunset yellow (20 mg/kg, p.o) for 30 days. Ethanol extract of Vernonia cinerea (EEVC) (400 mg/kg, p.o) administered, after 1 hour of sunset yellow treatment. Diazepam (1 mg/kg, p.o) was used as a reference drug.Results: FT-IR studies of the extract were done to determine the presence of phenols and flavonoids. Vernonia cinerea significantly improved the altered anxiogenic behaviour of sunset yellow treated animals. Significant increase in the brain antioxidant enzymes level and neurotransmitter Gamma-aminobutyric acid (GABA) level and decrease the lipid peroxidation and glutamate was observed in Vernonia cinerea treated group and also this extract reversed the hippocampus CA3 region abnormalities such as perivascular edema and hemorrhage in sunset yellow group. Conclusion: The Vernonia cinerea possesses significant antioxidant, antiradical, and GABA enhancing effects against sunset yellow-induced anxiogenic animals.

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Title
Sunset yellow induced neuronal damage; Protected by Vernonia cinerea : Exploration of the potential of Vernonia cinerea extract to attenuate the sunset yellow induced neuronal damage in mice
Author
Navaneetha Krishnan S
Publisher
LAP LAMBERT Academic Publishing
Publication year
2021
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6203839701
ISBN 13
9786203839708
Item weight
107 grams
Dimensions
220x150x5 mm

AHA-BUCH GmbH

Einbeck, Germany

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