Sunset yellow induced neuronal damage; Protected by Vernonia cinerea | Exploration of the potential of Vernonia cinerea extract to attenuate the sunset yellow induced neuronal damage in mice

Navaneetha Krishnan S (u. a.)

ISBN 10: 6203839701 / ISBN 13: 9786203839708

Published by LAP LAMBERT Academic Publishing, 2021

About this Item

Sunset yellow induced neuronal damage; Protected by Vernonia cinerea | Exploration of the potential of Vernonia cinerea extract to attenuate the sunset yellow induced neuronal damage in mice | Navaneetha Krishnan S (u. a.) | Taschenbuch | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786203839708 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 120008299

Bibliographic Details

• Title: Sunset yellow induced neuronal damage; Protected by Vernonia cinerea | Exploration of the potential of Vernonia cinerea extract to attenuate the sunset yellow induced neuronal damage in mice
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2021
• Language: English
• ISBN 10: 6203839701
• ISBN 13: 9786203839708
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 107 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Objective: The study was designed to screen the protective effect of Vernonia cinerea extract against sunset yellow induced anxiogenic behaviour in mice through counteracting oxidative damage.Methods: The anxiogenic effect was induced by the administration of sunset yellow (20 mg/kg, p.o) for 30 days. Ethanol extract of Vernonia cinerea (EEVC) (400 mg/kg, p.o) administered, after 1 hour of sunset yellow treatment. Diazepam (1 mg/kg, p.o) was used as a reference drug.Results: FT-IR studies of the extract were done to determine the presence of phenols and flavonoids. Vernonia cinerea significantly improved the altered anxiogenic behaviour of sunset yellow treated animals. Significant increase in the brain antioxidant enzymes level and neurotransmitter Gamma-aminobutyric acid (GABA) level and decrease the lipid peroxidation and glutamate was observed in Vernonia cinerea treated group and also this extract reversed the hippocampus CA3 region abnormalities such as perivascular edema and hemorrhage in sunset yellow group. Conclusion: The Vernonia cinerea possesses significant antioxidant, antiradical, and GABA enhancing effects against sunset yellow-induced anxiogenic animals.