Survival Analysis/A Self-Learning Text

This text on survival analysis provides a straightforward and easy-to-follow introduction to the main concepts and techniques of the subject. It is based on numerous courses given by the author to students and researchers in the health sciences and is written with such readers in mind. Throughout, there is an emphasis on presenting each new topic motivated with real examples of a survival analysis investigation, and then presenting thorough analyses of real data sets. Each chapter concludes with practice exercises to help readers reinforce their understanding of the concepts covered in the chapter. Readers can then extend their knowledge with a more thoroughgoing test. Answers to both are included. Beginning with the basic concepts of survival analysis-time to an event as a variable, censored data, and the hazard function-the author then introduces the Kaplan-Meier survival curves, the log-rank test, the Peto test, and the most widely used technique in survival analysis, the Cox proportional hazards model. Later chapters cover techniques for evaluating the proportional hazards assumptions, the stratified Cox procedure, and extending the Cox model to time-dependent variables. Readers will enjoy David Kleinbaum's style of presentation with numerous figures and diagrams illustrating each idea. As a result, this text makes an excellent introduction for all those coming to the subject for the first time.

This greatly expanded second edition of Survival Analysis- A Self-learning Text provides a highly readable description of state-of-the-art methods of analysis of survival/event-history data. This text is suitable for researchers and statisticians working in the medical and other life sciences as well as statisticians in academia who teach introductory and second-level courses on survival analysis. The second edition continues to use the unique "lecture-book" format of the first (1996) edition with the addition of three new chapters on advanced topics:

Chapter 7: Parametric Models

Chapter 8: Recurrent events

Chapter 9: Competing Risks.

Also, the Computer Appendix has been revised to provide step-by-step instructions for using the computer packages STATA (Version 7.0), SAS (Version 8.2), and SPSS (version 11.5) to carry out the procedures presented in the main text.

The original six chapters have been modified slightly

to expand and clarify aspects of survival analysis in response to suggestions by students, colleagues and reviewers, and

to add theoretical background, particularly regarding the formulation of the (partial) likelihood functions for proportional hazards, stratified, and extended Cox regression models

David Kleinbaum is Professor of Epidemiology at the Rollins School of Public Health at Emory University, Atlanta, Georgia. Dr. Kleinbaum is internationally known for innovative textbooks and teaching on epidemiological methods, multiple linear regression, logistic regression, and survival analysis. He has provided extensive worldwide short-course training in over 150 short courses on statistical and epidemiological methods. He is also the author of ActivEpi (2002), an interactive computer-based instructional text on fundamentals of epidemiology, which has been used in a variety of educational environments including distance learning.

Mitchel Klein is Research Assistant Professor with a joint appointment in the Department of Environmental and Occupational Health (EOH) and the Department of Epidemiology, also at the Rollins School of Public Health at Emory University. Dr. Klein is also co-author with Dr. Kleinbaum of the second edition of Logistic Regression- A Self-Learning Text (2002). He has regularly taught epidemiologic methods courses at Emory to graduate students in public health and in clinical medicine. He is responsible for the epidemiologic methods training of physicians enrolled in Emory’s Master of Science in Clinical Research Program, and has collaborated with Dr. Kleinbaum both nationally and internationally in teaching several short courses on various topics in epidemiologic methods.