Synthesis & Biological Evaluation Of 1,3,4 Oxadiazole Derivatives

Oxadiazole is a five mamboed heterocyclic aromatic compound having two carbon two nitrogen & one oxygen atom & two bonds having general formula Oxadiazole is consider to be derived from furan by replacement of two methane (CH=) group by two pyridine type nitrogen (-N=) called as furadiazoles. There are four possible isomer of oxadiazole depending on the position of nitrogen atom in the ring namely 1,2 ,3-oxadiazole 1, 2, 4 & 1 ,3, 4 oxadiazole. A large number of 1,3,4 oxadiazole derivatives have been found to exhibit various biological activities such as anti –inflammatory anti microbial anticancer anticonvulsant & anti hypertensive etc.

Vinit Raj (Department of Pharmaceutical sciences,Babasaheb Bhimrao Ambedkar University, Lucknow, India), Dr. Arvind Kumar (SD College of Pharmacy and Vocational studies,Muzaffarnagar, Uttar Pradesh, India) and Praveen Kumar (SD College of Pharmacy and Vocational studies, Muzaffarnagar, Uttar Pradesh, India)