Synthesis and Computational Applicaton of Quinoline

Dhaval B. Patel

ISBN 10: 6205521946 / ISBN 13: 9786205521946

Published by Scholars' Press Mär 2023, 2023

About this Item

Neuware -In summary, this work demonstrates the designing, synthesis and biological evaluation of novel 2-(2-chlorophenyl)quinoline-4-carboxylic acid hybrid thiosemicarbazides. The synthesized derivatives were evaluated for their variousin-vitro biological activities. Most of the compounds displayed excellent activity against gram-positive bacteria in comparison to gram-negative bacteria. Biological activity and docking results of quinoline derivatives makes interesting lead in drug development. The calculated ADME-Tox parameters suggest good pharmacokinetic properties. These studies disclose that active molecules are used as term plate for the development of active biological agents. Molecular dynamics simulation can be concluded that MD can be successfully implemented for new drug development and several promising inhibitor molecules.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 56 pp. Englisch.

Seller Inventory # 9786205521946

Bibliographic Details

• Title: Synthesis and Computational Applicaton of Quinoline
• Publisher: Scholars' Press Mär 2023
• Publication Date: 2023
• Language: English
• ISBN 10: 6205521946
• ISBN 13: 9786205521946
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 4D millimeters 220 millimeters width by 150 millimeters height by 4 millimeters depth
• Weight: 102 grams

About this title

Synopsis

In summary, this work demonstrates the designing, synthesis and biological evaluation of novel 2-(2-chlorophenyl)quinoline-4-carboxylic acid hybrid thiosemicarbazides. The synthesized derivatives were evaluated for their variousin-vitro biological activities. Most of the compounds displayed excellent activity against gram-positive bacteria in comparison to gram-negative bacteria. Biological activity and docking results of quinoline derivatives makes interesting lead in drug development. The calculated ADME-Tox parameters suggest good pharmacokinetic properties. These studies disclose that active molecules are used as term plate for the development of active biological agents. Molecular dynamics simulation can be concluded that MD can be successfully implemented for new drug development and several promising inhibitor molecules.