Synthesis of Heterocycles via Cycloadditions I

Alfred Hassner

ISBN 10: 3642097081 / ISBN 13: 9783642097089

Published by Springer Berlin Heidelberg, Springer, 2010

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Heterocyclicmoleculesplayasigni cantroleinlifeprocessesandhaveplayed a major rolein industrial developments of the last century, for instance in the eld of dyes, pharmaceuticals, pesticides, polymers etc. They comprise not onlysomeofthemostinterestingandbiologicallyimportantnaturalproducts like alkaloids, carbohydrates, nucleic acids, and antibiotics but include many practical drugs and a large segment of known synthetic organic compounds. Hencescientistshavedevotedagreatamountofeffortto ndoptimalsynthetic approachesto a variety ofheterocyclic compounds. Amongthemostsuccessfulandselectivesyntheticprocessesarecycload- tionreactions,since theyinvolvesimultaneous orsequential formationoftwo ormorebondsoftenwithahighdegreeofstereoselectivityandregioselectivity. Forinstance, 1,3 dipolar cycloadditionsareelectronicallyequivalent to Diels Alder reactions and are among the most common 5-membered ring-forming systems. In addition they usually proceed with a high degree of stereo- and regio-control.It is therefore, not surprising that synthesis of many important classesofheterocycles,includingthoseofusefulbiologicallyactivemolecules, haveutilized cycloadditionsteps intheir formation.Furthermore,manyhe- rocyclesserve as intermediates in the synthesis of polyfunctional molecules. In this volume we present ve selected contributions by well-known - thors, each an authority in his eld. The rst chapter deals with construction ofisoxazolines(dihydroisoxazoles)via1,3-dipolarcycloadditionsofnitronates or of nitrile oxides generated from nitroalkanes. This includes inter- as well as intramolecular processes. Many of these heterocycles possess important synthetic and biological properties and are shown to lead to stereo- and - gioselectiveintroductionofmultifunctionalmoleculessuchasaminoalcohols, -amino acids, aldols, nitriles, and others.

Seller Inventory # 9783642097089

Bibliographic Details

• Title: Synthesis of Heterocycles via Cycloadditions I
• Publisher: Springer Berlin Heidelberg, Springer
• Publication Date: 2010
• Language: English
• ISBN 10: 3642097081
• ISBN 13: 9783642097089
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 14D millimeters 235 millimeters width by 155 millimeters height by 14 millimeters depth
• Weight: 376 grams

About this title

Synopsis

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers hot topics of frontier research summarized by reputed scientists in the field.

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